Year : 2019 | Volume : 7 | Issue : 2 | Page : 62 - 64  

Original Articles
Comparative Evaluation of Bolus Administration of Esmolol and Fentanyl for Attenuation of Pressor Response during Laryngoscopy and Endotracheal Intubation

Rajabhushanam M 1, Sunil Kumar K 2*, SA Aasim 3, Vimalatha P 4 

1,2Associate Professor, 3Professor, 4 PG Student, Department of Anesthesiology, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, Telangana, India. 

*Corresponding author:

Dr. K. Sunil Kumar                                                                                                              



Background: The haemodynamic responses to laryngoscopy and endotracheal intubation have been recognized since 1951.

Objective: To compare the efficacy of bolus administration of IV Esmolol and IV Fentanyl to suppress the pressor response during laryngoscopy and endotracheal intubation.

Methods: 75 patients of ASA physical status I & II undergoing elective surgical procedure under General Anesthesia with endotracheal intubation were included in the study. Patients belonging to age group of 18-60 years of both sexes were included. The present study was done at Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar during 2014 to 2016.

Results: Total 75 patients under this study were categorized into 3 groups. They comprised both sexes with age ranging from 18-60 years. There is high statistically significant difference in mean heart rate across the 3 groups (p < 0.001). The mean heart rate, blood pressure and mean arterial pressure of the esmolol group are the least and this difference with the control group and fentanyl group are statistically significant.

Conclusion: We concluded that bolus injection of esmolol (2mg/kg) given 3 minutes prior to intubation provided consistent and reliable protection against increases in mean heart rate and mean systolic and diastolic blood pressure during laryngoscopy and endotracheal intubation and thereafter, compared to control group and fentanyl group.

Keywords: Esmolol, Fentanyl, laryngoscopy, endotracheal intubation


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