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Year : 2019 | Volume : 7 | Issue : 3 | Page : 73 - 76  


Original Articles
Attenuation of Cardiovascular response to Intubation: A double blind Comparative study of Esmolol and Lignocaine with hemodynamic response

Sunil Kumar K 1, Kishore K2*, Syed Ali Aasim3, Inugula Rajkumar Reddy 4, Rajesh Verma 4

1, 4Assoc. Professor, 3Professor, 4Resident, Department of Anesthesiology, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, Telangana, India.

Correspondence:

Dr. K. Kishore                                                                                                                                     

E-mail: saisahasra28@gmail.com                                                                                                  

Abstract:

Background: The present study aim was to determine the efficacy of lignocaine 2 mg/kg bolus and esmolol 200 mg bolus in attenuating the sympathetic responses to laryngoscopy and tracheal intubation.

Objective: To determine the efficacy of lignocaine 2 mg/kg bolus and esmolol 200 mg bolus in attenuating the sympathetic responses to laryngoscopy and tracheal intubation

Methods: A clinical comparative study of attenuation of sympathetic response to laryngoscopy and intubation was done in 150 patients posted for elective surgeries. Study was conducted in Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar. General Anesthesia was provided with endotracheal Intubation for all the patients. 150 cases were divided into three groups with 50 cases in each group. An informed consent was taken in all the patients.

Results: The age range was 20-50 years for control and study groups. The mean values of age with standard deviations are 31.18±9.79, 32.18±10.64 and 33.66±10.83 for control, lignocaine and esmolol groups respectively. In combination of esmolol and lignocaine test dose a significant decrease in SBP occurred after 1min (p <0.001), and 3 min (p <0.001) groups respectively.

Conclusion: Among the both study groups superiority of esmolol over lignocaine in attenuating the sympathetic responses to laryngoscopy and intubation is evident and statistically highly significant at all times.

Keywords: Attenuation, cardiovascular response, esmolol, lignocaine





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